Matt Maciejewski, PhD

About

CEO at MatGen, a computational drug discovery partner providing hands-on analysis, coding, and technical execution across data science, bioinformatics/comp bio, and cheminformatics/comp chem. Reach out if you're interested in collaborating. I'm also available for consulting, as well as SAB or BoD roles in these areas.

Previously, I led a group at a gene editing company using a cross-section of computational methods to design RNA-editing oligonucleotides (now in clinical trials).

Throughout my career (including Pfizer, Novartis, NIH), I have used machine learning and probabilistic modeling to improve our understanding of diseases and design new treatments.

Building something new at the intersection of AI & biotech.

Work and Education

More complete info available on LinkedIn

Industrial Experience

• Founder and CEO, January 2025 - Present
  MatGen, Cambridge MA → reach out to us for computational services (spanning the full computational drug discovery stack).

• Founder, January 2025 - Present
  Stealth Mode Biotech, Cambridge MA

• Vice President, Head of Data Science, June 2022 - December 2024
  Korro Bio, Cambridge MA

• Head of Data Science, December 2014 - May 2022
  Pfizer Inc., Cambridge MA

• Founder and CEO at DrugRev, 2014 - 2019

• Presidential Postdoctoral Fellow, May 2013 - November 2014
  Novartis Institutes for BioMedical Research, Cambridge MA

• Co-founder and CTO at DocDx, November 2012 - September 2014

Academic Experience

• Visiting Postdoctoral Researcher, May 2012 - May 2013
  University of Cambridge, Cambridge UK
  and University of Edinburgh, Edinburgh UK

PhD

• Wellcome Trust - NIH scholarship for collaborative graduate research,
  October 2008 - May 2012

• Graduate Researcher at Tjandra Lab
  National Institutes of Health, Bethesda MD

• PhD Candidate at Barlow Lab
  University of Edinburgh, Edinburgh UK

• Thesis "Structure and Dynamics of Proteins that Inhibit Complement Activation"

Undergraduate

BSc, 1^st Class Honors, 2008
University of Edinburgh, Edinburgh UK

Music

Before I went to university, music was a huge part of my life. Who knows, maybe one day I'll give it another shot.

Mind Gate

Through high school (and the first two years of university), I played guitar in a band called Mind Gate. In its lifetime, Mind Gate gave a bunch of concerts, interviews, and most importantly, released three demo albums.

Our final demo (called "Spiral") was officially released by an Italian record label company, Lucretia Records, and is still available on Amazon. There's also a lot of Mind Gate music available on our Myspace page - I think two whole albums - and there's a fan video on Youtube (!). Enjoy!